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Jaguars odds, while the over/under for total points scored is 40.5. New Orleans is a two-point favorite in the latest Saints vs. Kickoff from Caesars Superdome is set for 8:15 p.m. New Orleans (3-3) has dropped three of its last four games after falling 20-13 at Houston last Sunday. The Jaguars could be without quarterback Trevor Lawrence for this matchup, as the star quarterback is questionable with a knee sprain. Jacksonville (4-2) is coming off its third consecutive victory, a 37-20 triumph over Indianapolis, but has lost four straight overall meetings with the Saints and all of its previous three contests in the Big Easy. The Jacksonville Jaguars will attempt to extend one streak and halt another when they get Week 7 of the 2023 NFL season started by visiting the New Orleans Saints on Thursday Night Football.